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KMID : 1161520120160050385
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Animal Cells and Systems
2012 Volume.16 No. 5 p.385 ~ p.390
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Various pain stimulations cause an increase of the blood glucose level
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Sim Yun-Beom
Park Soo-Hyun
Kang Yu-Jung
Jung Jun-Sub
Ryu Ohk-Hyun
Choi Moon-Gi
Suh Hong-Won
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Abstract
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The relationship between pain stimulation and the blood glucose level was studied in ICR mice. We examined the possible change of the blood glucose level after the pain stimulation induced by acetic acid injected intraperitoneally (i.p.),, formalin injected subcutaneously (s.c.) into the hind paw, or substance P (SP), glutamate, and pro-inflammatory cytokines (TNF-α and IFN-γ) injected intrathecally (i.t.). We found in the present study that acetic acid, formalin, SP, TNF-α, and IFN-γ increased the blood glucose level. The blood glucose level reached at maximal state 30 min and returned to normal level 2 h after the pain stimulation in a fasting group. Furthermore, acetic acid, formalin, SP, TNF-α, and IFN-γ caused the elevation of the blood glucose level in d-glucose-fed group only in an additive manner. However, i.t. injection of glutamate did not alter the blood glucose level in a fasting group. In contrast, i.t. injection of glutamate enhanced the blood glucose level in the d-glucose-fed group. Our results suggest that the blood glucose level appears to be differentially regulated by various pain stimulation induced by acetic acid, formalin, SP, glutamate, and pro-inflammatory cytokines.
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KEYWORD
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pain, blood glucose level, acetic acid, formalin, substance P, glutamate, pro-inflammatory cytokine
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